- First appearance of both Billy Gibbons and Ty Panitz, who play Angela's dad and Booth's son Parker respectively.
- Hodgins calls Brennan the Grinch while trying to decide what to give Angela for Christmas. T.J. Thyne (Hodgins) played Stu Lou Who in How the Grinch Stole Christmas (2000).
- 1943 Philadelphia mint copper pennies regularly sell for over $200,000 in almost uncirculated condition to over $750,000 in mint state 63+ at auction. There are also examples found to have been minted at the Denver and San Francisco.mints. There are over the twelve as stated by Bones but the numbers are very low. At the time of the characters death they sold for over $8,000..
- Jim Ortlieb and David Boreanaz both appeared together on the television show Angel (1999).
- This is the first time we see Hodgins & Zach without a shirt.
Goofs
- When Brennan and Hodgins are talking about who is missing out on what this Christmas, Hodgins says Goodman is missing his family and Zack doesn't get to see his kids. He switched characters. Zack is missing out on seeing his family and Goodman is missing his kids.
- When Booth leaves the lab, he is carrying his coat and nothing else. Later on, at Wong Foo's, he gives the robot that Zack made to Parker.
- When Dr. Brennan is looking at her microscope, Booth approaches her and takes one of the photographs next to the microscope and turns it face down. After the close-up shot of Brennan, the photo is shown face up.
- Booth, Brennan, and Dr. Goodman are sitting on the catwalk discussing a case. Angela comes on scene and talks to them from downstairs. This prompts Brennan to get up and leave. Yet when the frame goes back to Angela looking at Booth and Dr. Goodman, you can still see Brennan sitting to the right.
- When Angela is asking for Brennan's help to celebrate Christmas while quarantined, the straps on Brennan's top and bra change positions between the long overhead shots and the close-up shots.
- While Valley Fever is transmitted by spores, it is not contagious and does not get spread by people breathing. There was no reason for the quarantine.
- While Valley Fever is transmitted by spores, it is not contagious and does not get spread by people breathing. There was no reason for the quarantine.
- When Booth was injected with the antifungal drug (stated to be amphotericin B), the medicine didn't have enough time to be dispersed into his blood stream - he wouldn't have been affected by the medicine that quickly. The injectable portion (amphotericin B) of the regimen would be given by slow intravenous infusion, not by intramuscular injection into the gluteal musculature as portrayed.
- While searching online for information we see Dr. Brennan using an AOL account. This seems quite odd as she would have to have access to the best computer programs and search engines. This takes place seven years after Google was launched in 1998.
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Interesting huh?